Tyrosine hydroxylase activity in Venezuelan equine encephalomyelitis virus infection |
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| Authors: | Sulamita Levine Ernesto Bonilla Slavia Ryder Mario Salazar Pedro Rangel |
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| Affiliation: | (1) Instituto de Investigaciones Clínicas Facultad de Medicina, Universidad del Zulia, Apartado 1151, Maracaibo, Venezuela |
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| Abstract: | In rats inoculated with the Venezuelan equine encephalomyelitis (VEE) virus, a significant decrease was found in the tyrosine hydroxylase activity of neostriatum, midbrain, and hypothalamus during the acute phase of the infection. In animals that survived the acute infection, we observed no changes in the enzymatic activity in the same regions studied. Our findings suggest a vulnerability of the dopaminergic and noradrenergic pathways to the infection produced by VEE virus. |
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