| 窦内压升高和灌流腺苷激活颈动脉窦压力感受器时延髓内c-fos蛋白的表达 |
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| 引用本文： | Chen S,Zhang XX,Shi GM,He RR. 窦内压升高和灌流腺苷激活颈动脉窦压力感受器时延髓内c-fos蛋白的表达[J]. 生理学报, 1999, 0(2): 193-198 |
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| 作者姓名： | Chen S Zhang XX Shi GM He RR |
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| 作者单位： | 1. 河北医科大学基础所生理室,石家庄,050017
2. 河北医科大学解剖室,石家庄,050017 |
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| 摘 要： | 在14 只隔离灌流颈动脉窦区的大鼠, 观察了窦内压(ISP) 升高和灌流腺苷 (adenosine, Ado) 激活压力感受器时延髓内c-fos蛋白的表达.结果显示: 在孤束核、最后区、延髓腹外侧头端区和中缝苍白核可见Fos蛋白样免疫阳性反应(FLI)神经元分布, 且其数量随ISP升高而增多.在给定ISP下, 颈动脉窦内灌流Ado, 可使上述区域中FLI表达明显增多.根据以上结果, 得出如下结论: c-fos在压力感受器反射延髓通路中的表达, 可由ISP增高和灌流Ado而增强, 表明Ado对压力感受器反射有易化作用.
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| 关 键 词： | c－fos 窦内压 腺苷 压力感受器 颈动脉窦 |
Expression of c-fos in the medulla oblongata after carotid baroreceptor activation by elevated intrasinus pressure and adenosine |
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| Chen S,Zhang X X,Shi G M,He R R. Expression of c-fos in the medulla oblongata after carotid baroreceptor activation by elevated intrasinus pressure and adenosine[J]. Acta Physiologica Sinica, 1999, 0(2): 193-198 |
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| Authors: | Chen S Zhang X X Shi G M He R R |
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| Affiliation: | Department of Physiology, Hebei Medical University, Shijiazhuang 050017. |
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| Abstract: | Expression of c-fos protein in the medulla oblongata after baroreceptor activation by elevated intrasinus pressure (ISP) and perfusion of adenosine (Ado) was examined in 14 vascularly isolated carotid sinus perfusion rats. The results showed that Fos-like immunoreactive (FLI) neurons were distributed throughout nucleus tractus solitarius, area postrema, rostral ventrolateral medulla and nucleus raphe pallidus, and the number of FLI was increased with the elevation of ISP. Furthermore, perfusing the carotid sinus with Ado at a given ISP markedly increased the FLI in the above regions. From the results obtained, it is concluded that the c-fos expression in baroreflex pathway in medulla oblongata may be enhanced by elevated ISP and intrasinus perfusion of Ado, and Ado is capable of facilitating the baroreflex. |
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| Keywords: | c-fos c-fos intrasinus pressure adenosine |
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