| 一个人类新基因ZNF322的研究初报 |
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| 引用本文： | 李永青,曾伟奇,朱传炳,皮花亮,戴琦,吴秀山.一个人类新基因ZNF322的研究初报[J].生命科学研究,2001,5(2):141-145. |
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| 作者姓名： | 李永青 曾伟奇 朱传炳 皮花亮 戴琦 吴秀山 |
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| 作者单位： | 湖南师范大学生命科学学院, |
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| 基金项目： | 湖南省特聘教授基金(25000613) |
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| 摘 要： | 利用果蝇心脏发育基因zfh-1的cDNA序列和计算机克隆方法，在9号染色体上发现了一个新的人类同源基因，经国际基因全程委员会批准，命名为ZNF322。该基因总长度约为2.8kb，为一个连续的序列，编码一个402个氨基酸的蛋白质，与小鼠zfp-25编码的蛋白质最相似（同源度为51.4%）。该基因在人体肾、脑、结肠、胚胎心脏及黑色素瘤等多种组织中广泛表达，其功能有等深入研究。
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| 关 键 词： | ZNF322基因 计算机克隆 新基因 |
| 文章编号： | 1007-7847(2001)02-0141-05 |
| 修稿时间： | 2001年1月16日 |
Primary Studies on a Novel
Human ZNF322 Gene |
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| LI Yongqing,ZENG Weiqi,ZHU Chuanbing,PI Hualiang,DAI Qi,WU Xiushan.Primary Studies on a Novel
Human ZNF322 Gene[J].Life Science Research,2001,5(2):141-145. |
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| Authors: | LI Yongqing ZENG Weiqi ZHU Chuanbing PI Hualiang DAI Qi WU Xiushan |
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| Abstract: | Based on the cDNA sequence of the zfh -1 gene in Drosophila , a novel human homolog located on chromosome 9 was found by computer cloning method. The gene is named ZNF 322, which is approved by HUGO Gene Nomeclature Committee. Its mRNA is about 2.8 kb and there is no intron in it. The gene encodes a protein of 402 amino acids,which is the best similar to the mouse protein encoded by zfp -35 (51.4%). Its ESTs appeared in many kinds normal tissues, such as kidney, brain, colon and fetal heart, and in melanoma or other tumor tissues. The function of the gene remains to be studied. |
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| Keywords: | ZNF 322 gene computer cloning novel gene |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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