A comparison of in vitro anticancerous activity and mechanism of ethanolic extracts from different Ganoderma genus |
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| Authors: | Zhou Yueqin Yang Xiaotong Li Xuquan Feng Huiqin Mi Ke and Yang Qingyao |
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| Institution: | (1) Institute of Microbiology and Immunology, Life and Environment Science College, Shanghai Normal University, Shanghai, 200234, China;(2) 8th floor, Building No. 14th 100 Guilin Road, Shanghai, 200234, China |
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| Abstract: | Five ethanolic extracts from the mycelia of Ganoderma lucidum, G. tsugae, G. oerstedii, G. subamboinense, and G. resinaceum were respectively studied on their anticancerous activities against leukemic HL-60 cell line in vitro. Results showed that
all five extracts potently inhibited HL-60 proliferation. The extract from G. lucidum mycelia exerted the highest activity. Annexin V/PI bivariate flow cytometric analysis further revealed that the five extracts
significantly induced early apoptosis in HL-60 cells. The results illustrate that not only G. lucidum but also other Ganoderma species can inhibit cancer cells, and their mechanisms are related to induction of apoptosis.
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Translated from Journal of Shanghai Normal University (Natural Sciences), 2005, 34(2): 77–81 译自: 上海师范大学学报 (自然科学版), 2005, 34(2): 77–81] |
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| Keywords: | Ganoderma anti-proliferation apoptosis HL-60 |
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