Vascular permeability-increasing activity possessed byTreponema phagedenis (Reiter strain) |
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Authors: | Takao Sugahara Shun-ichi Yamaya Dr Tomoko Takahashi |
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Institution: | (1) Department of Applied Immunology, National Institute of Health, Shinagawa-ku, 142 Tokyo, Japan;(2) Hoshi College of Pharmacy, Shinagawa-ku, Tokyo, Japan |
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Abstract: | Treponema phagedenis possessed the ability to induce an increase in vascular permeability (blueing) in guinea pig skin, which was exerted not only by cell-free preparations but also directly by intact cells. Cell-free preparations induced maximum blueing 0 h after sample injection, while whole cells did so after 1 h. Log dose-response curves for cell-free preparations were linear within the range of blue spots with diameters of 10–24 mm, with slopes (
) of 8.5–8.7. The vascular permeability-increasing activity was not ascribable to hyaluronidase and probably to -galactosidase; this organism did not produce any detectable hyaluronidase activity. |
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