Cloning and characterization of a Caenorhabditis elegans cDNA encoding a new insulin/IGF-like peptide |
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Authors: | Kawano Tsuyoshi Takuwa Kyoko Ishiguro Masaji Nakajima Terumi Kimura Yasuo |
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Affiliation: | Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University, Japan. kawano@muses.tottori-u.ac.jp |
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Abstract: | A Caenorhabditis elegans cDNA encoding a new insulin/IGF-like peptide was cloned and examined. The predicted peptide shows significant sequence similarity with the peptide Ceinsulin-1 reported previously and contains a characteristic insertion consisting of three residues in the putative B domain as with the Ceinsulin-1. The gene expression pattern during development is almost identical to that of Ceinsulin-1. The predicted tertiary structure of the peptide is quite similar to that of Ceinsulin-1, and their predicted receptor-recognition surfaces also closely match. These facts suggest that both peptides could recognize the same receptor. |
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