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Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients
Institution:1. Max Planck Research Unit for Neurogenetics, Frankfurt, Germany;2. Department of Neurosciences, Experimental Otorhinolaryngology, Rhinology Research, KU Leuven, Leuven, Belgium;3. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium;4. Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium;5. Department of Otorhinolaryngology, Head and Neck Surgery, AZ Sint-Jan Brugge-Oostende AV, Bruges, Belgium;6. Department of Neurosurgery, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium;7. Department of Infectious Diseases, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium;8. Department of Otorhinolaryngology - Head and Neck Surgery, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium;9. Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, Republic of Korea;10. Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Leuven, Belgium;11. Department of Laboratory Medicine & National Reference Center for Respiratory Pathogens, University Hospitals Leuven, Leuven, Belgium;12. Intensive Care Medicine, University Hospitals Leuven, Leuven, Belgium;13. Department of Cellular and Molecular Medicine, Laboratory of Intensive Care Medicine, KU Leuven, Leuven, Belgium;14. Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium;15. Department of Microbiology, Immunology and Transplantation, Laboratory for Clinical Infectious and Inflammatory Disorders, KU Leuven, Leuven, Belgium;16. Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical Bacteriology and Mycology, KU Leuven, Leuven, Belgium;17. Department of Pathology, University Hospitals Leuven, Leuven, Belgium;18. Laboratory of Neuropathology, Department of Imaging & Pathology and Leuven Brain Institute, KU Leuven, Leuven, Belgium;19. Department of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium;20. Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
Abstract:
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  • Keywords:COVID-19  SARS-CoV-2  Coronavirus  Delta  Omicron  olfactory  olfactory sensory neuron  perineurial olfactory nerve fibroblast  olfactory bulb  leptomeninges  brain parenchyma  frontal lobe  neurotropism  neuroinvasion  blood-brain barrier  Virchow-Robin space  glia limitans perivascularis  RNAscope
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