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A brain atlas of synapse protein lifetime across the mouse lifespan
Affiliation:1. Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK;2. School of Computing, Edinburgh Napier University, Edinburgh EH10 5DT, UK;3. Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA;4. Integrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA;5. Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, UPM, 28223 Madrid, Spain;6. Instituto Cajal, CSIC, 28002 Madrid, Spain;7. Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland;8. Centre for Inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK;9. Simons Initiative for the Developing Brain (SIDB), Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK;10. The Patrick Wild Centre for Research into Autism, Fragile X Syndrome & Intellectual Disabilities, Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK;11. Muir Maxwell Epilepsy Centre, University of Edinburgh, Edinburgh EH8 9XD, UK;12. Department of Computational Science and Technology, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, 10044 Stockholm, Sweden;13. Science for Life Laboratory, KTH Royal Institute of Technology, 171 65 Solna, Sweden
Abstract:
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  • Keywords:synapse proteome  postsynaptic density  proteostasis  synaptome  protein turnover  aging  brain development  autism  dendritic spine  pyramidal neuron  HaloTag
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