The therapeutic responses to I-131 ablation in patients of differentiated thyroid carcinoma complicated with nodular goiter |
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| Affiliation: | 1. Department of Nuclear Medicine, Shanghai Jiao-Tong University Affiliated Sixth People''s Hospital, Shanghai, People''s Republic of China;2. Department of Gynaecology and Obstetrics, Fudan University, Shanghai Pudong Hospital, Shanghai, People''s Republic of China;1. Service de médecine nucléaire, centre hospitalier régional universitaire de Besançon, Besançon, France;2. Service de médecine nucléaire, hôpital Nord Franche Comté, Trevenans, France;1. Department of Nuclear Medicine, European & Center for Research in Medical Imaging, Aix-Marseille University, 13385 Marseille, France;2. Service de médecine nucléaire, centre cardiologique du Nord, 93200 Saint-Denis, France;3. Service de médecine nucléaire, CHU de Grenoble, 38700 La-Tronche, France;4. Service de médecine nucléaire, CHU de Henri-Mondor, 94010 Créteil, France;5. Ligue contre le cancer, France;6. Service de médecine nucléaire, CHU de Cochin, 75014 Paris, France;7. Service de médecine nucléaire, CHU de Montpellier, 34090 Montpellier, France;8. Service de médecine nucléaire, CHU de Lille, 59000 Lille, France;9. Service de médecine nucléaire, institut de cancérologie privé, 34170 Castelnau-le-Lez, France;10. Service de médecine nucléaire, CH de Albi, 81000 Albi, France;11. Service de médecine nucléaire, AP–HM, 13005 Marseille, France;1. Department of Internal Medicine, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil;2. Medical Student, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil;3. Department of Internal Medicine, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil;4. Department of Anatomy and Imaging, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil;1. Shanghai Institute of Medical Imaging, Shanghai 200032, China;2. Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, 180, Fenglin road, Shanghai 200032, China;3. Nuclear Medicine Institute of Fudan University, Shanghai 200032, China;4. Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China;1. Nuclear Medicine and Molecular Imaging Department, Lausanne University Hospital, Lausanne, Switzerland;2. Inserm U1060, CarMeN laboratory, university of Lyon, Lyon, France;3. University of Lausanne, Lausanne, Switzerland |
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| Abstract: | IntroductionWe applied the response to therapy reclassification system (RTRS) to evaluate the disease status after surgery and I-131 therapy in differentiated thyroid carcinoma (DTC) patients with nodular goiter (NG).Materials and methodsA total of 268 DTC complicated with NG patients who underwent the I-131 treatment and thyroidectomy between 2010 and 2018 were analyzed. The RTRS were classified into excellent (ER), indeterminate (IDR), biochemical incomplete (BIR) and structural incomplete response (SIR). Logistic regression analysis were performed to evaluate the relevant clinicopathologic and laboratory variables in the prediction of non-ER (IDR, BIR and SIR).ResultsIn the logistic analysis, gender (OR: 3.543, P = 0.01), lateral cervical lymph node metastases (N1b) (OR: 6.646, P = 0.005), pre-ablation stimulated thyroglobulin (Ps-Tg) (OR: 0.859, P = 0.000), and anti-Tg antibody (TgAb) (OR: 64.546, P = 0.000) were predictor of non-ER. The cut-off value of ps-Tg for predicting the ER was 19.98 ng/mL with a sensitivity of 92.6% and specificity of 83.2%. The non-ER rate of N1b group was significantly higher than the central cervical LNM (N1a) group.ConclusionFor patients with DTC complicated with NG, the cut-off value of ps-Tg for predicting the ER was 19.98 ng/mL. N1b patients showed inferior responses to I-131 therapy compared to N1a patients. |
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| Keywords: | Differentiated thyroid carcinoma (DTC) Nodular goiter (NG) Pre-ablation stimulated thyroglobulin (Ps-Tg) Lateral Cervical Lymph Node Metastases (N1b) I-131 therapy Carcinome thyroïdien différencié (DTC) Goitre nodulaire (NG) Thyroglobuline stimulée avant l’ablation (Ps-Tg) Métastases des ganglions lymphatiques cervicaux latéraux (N1b) Thérapie à l’I-131 |
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