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Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2
Institution:1. Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;2. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;3. Child Health Institute of New Jersey, New Brunswick, NJ 08901, USA;4. Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, NJ 08901, USA;5. Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;6. Department of Pediatrics, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, NJ 08901, USA;7. School of Biological Sciences, Victoria University of Wellington, Wellington 6140, New Zealand;8. German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany;9. Department of Neuroproteomics, School of Medicine, Klinikum rechts der Isar, and Institute for Advanced Study, Technical University of Munich, 81675 Munich, Germany;10. Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany;11. Center for Autism and Neurodevelopment, Northwestern University, Chicago, IL 60611, USA;12. Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;13. Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
Abstract:
Keywords:ectodomain shedding  autism  schizophrenia  cerebrospinal fluid  sheddome  CNTNAP2  calcium  network dynamics  proteomics  bioinformatics
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