Developmental Expression of Transferrin Binding Protein in Oligodendrocyte Lineage Cells of the Embryonic Chick Spinal Cord |
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Authors: | Sang Wook Park Ha Seong Lim Eun Jung Roh Dong Woon Kim Gye Sun Jeon Sa Sun Cho |
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Affiliation: | (1) Department of Anatomy, Seoul National University College of Medicine, 28, Yongon-Dong, Chongno-Gu, Seoul, 110-799, Korea;(2) Department of Anatomy, Chungnam National University College of Medicine, 6, Munhwa-Dong, Chung-Gu, Daejeon, 301-131, Korea;(3) MRC Neuroscience Institute, Seoul National University College of Medicine, 28, Yongon-Dong, Chongno-Gu, Seoul, 110-799, Korea |
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Abstract: | Oligodendrocytes develop from precursor cells in the neuroepithelium of the ventral ventricular zone. Oligodendrocytes in the different stages of development are characterized by expression of a number of different marker molecules such as myelin genes, growth factors, and specific antigens. We have previously identified that transferrin binding protein (TfBP), a member of heat shock protein 90 families, is a novel avian ER-associated membrane protein that is specifically localized in oligodendrocytes in adult chicken CNS. In this study we describe the developmental expression of TfBP in the embryonic chick spinal cord. A few, distinct, TfBP+ cells appeared at the lateral margin of the subventricular neuroepithelium of the spinal cord at E7. Thereafter, some TfBP+ cells, exhibited a migrative form of unipolar or bipolar shape occurred around E8 in the mantle layer, midway between the neuroepithelium and the marginal layer of the primitive spinal cord. Thereafter, the TfBP+ cells rapidly increased in number as well as their staining intensity, and overall distribution of TfBP+ cells at E15 was comparable to that of a mature spinal cord. Our observations suggest that TfBP is expressed in the subpopulation of oligodednrcyte lineage in the development and a putative role of TfBP in relation to transferrin and iron trafficking is considered. SW Park and HS Lim contributed equally to this work. |
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Keywords: | Oligodendrocyte precursors Subpopulation Spinal cord Chick embryo |
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