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Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification |
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| Authors: | Heightman Tom D Scott Jackie S Longley Mark Bordas Vincent Dean David K Elliott Richard Hutley Gail Witherington Jason Abberley Lee Passingham Barry Berlanga Manuela de Los Frailes Maite Wise Alan Powney Ben Muir Alison McKay Fiona Butler Sharon Winborn Kim Gardner Christopher Darton Jill Campbell Colin Sanger Gareth |
| Affiliation: | Department of Medicinal Chemistry & DMPK, Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. Tom.D.Heightman@gsk.com |
| Abstract: | High throughput screening combined with efficient datamining and parallel synthesis led to the discovery of a novel series of indolines showing potent in vitro ghrelin receptor agonist activity and acceleration of gastric emptying in rats. |
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