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Protein Complex Assemblies in Epithelial Cell Polarity and Asymmetric Cell Division |
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| Authors: | Wenyu Wen Mingjie Zhang |
| Affiliation: | 1. Department of Neurosurgery, Huashan Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai 200040, China;2. Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, PR China;3. Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China;4. Center of Systems Biology and Human Health, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China |
| Abstract: | Asymmetric local concentration of protein complexes on distinct membrane regions is a fundamental property in numerous biological processes and is a hallmark of cell polarity. Evolutionarily conserved core polarity proteins form specific and dynamic networks to regulate the establishment and maintenance of cell polarity, as well as distinct polarity-driven cellular events. This review focuses on the molecular and structural basis governing regulated formation of several sets of core cell polarity regulatory complexes, as well as their functions in epithelial cell polarization and asymmetric cell division. |
| Keywords: | Protein complex assembly Polarity proteins Epithelial cell polarity Asymmetric cell division Par complex Par complex Par3/Par6/aPKC complex Crb Crumbs Scrib Scribble TJ tight junction AJ adherens junction PIP phosphatidylinositide phosphate aPKC atypical protein kinase C NB neuroblast NTD N-terminal domain Insc Inscuteable Pins Partner of inscuteable Pros Prospero Brat brain tumor Stau Staufen Pon Partner of Numb Mira Miranda GMC ganglion mother cell TPR tetratricopeptide repeat CBD cargo binding domain GL GoLoco Khc73 kinesin heavy chain 73 CT cytoplasmic tail FBM FERM-binding motif PBM PDZ-binding motif GK guanylate kinase PSG PDZ–SH3–GK Lgl Lethal Giant Larvae ACD asymmetric cell division JAM Junctional Adhesion Molecule |
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