A study on the estimation of sulfur-containing amino acid metabolism by the determination of urinary sulfate and taurine |
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Authors: | Nakamura H Kajikawa R Ubuka T |
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Institution: | (1) Department of Clinical Nutrition, Kawasaki University of Medical Welfare, Kurashiki, Okayama, Japan, JP |
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Abstract: | Summary. Sulfate and taurine are major end products of sulfur-containing amino acid metabolism in mammals including humans, and they
are excreted in urine. Average excretions (μmol/mg of creatinine) in the morning urine of 58 female college students were: total (free plus ester) sulfate (a), 12.53
± 3.85; free sulfate, 11.57 ± 3.69; taurine, 0.78 ± 0.53. Ratio of total sulfate and taurine was 10 : 0.6. Regression lines
obtained by plotting total sulfate, free sulfate, or total sulfate plus taurine against urea have shown that the former excretions
are significantly correlated with urea excretion. Excretion of total sulfate at zero point of urea excretion (b) was 5.30,
which corresponded to 42.3% of average excretion (12.53) and was assumed to be derived from dietary sulfate. The difference
7.23 (a − b) seemed to be derived from sulfur-containing amino acids. It was pointed out that the difference of average sulfate
excretion and sulfate excretion at zero urea excretion, namely a − b, was appropriate for the metabolic index of sulfur-containing
amino acids of the group examined. As free sulfate constituted 92.3% of total sulfate, excretion of ester sulfate was at a
constant level, and that of taurine was not significantly correlated with urea excretion, the value of free sulfate corresponding
to the value a − b of total sulfate mentioned above seemed to be a reliable and convenient index in the assessment of sulfur-containing
amino acid metabolism.
Received December 3, 2001 Accepted January 2, 2002 Published online August 30, 2002
Authors' address: Dr. Toshihiko Ubuka, Department of Clinical Nutrition, Kawasaki University of Medical Welfare, Kurashiki Okayama, 701-0193
Japan, E-mail: ubukatos@mw.kawasaki-m.ac.jp |
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Keywords: | : Amino acids Sulfur-containing amino acids Sulfate Taurine Metabolic index |
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