The repair of x-ray-induced chromosome aberrations in stimulated and unstimulated human lymphocytes |
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Authors: | S Wolff |
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Affiliation: | Laboratory of Radiobiology and Department of Anatomy, University of California, San Francisco, Calif. 94122, U.S.A. |
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Abstract: | The repair time for chromosome breaks induced by X-irradiation of unstimulated (G0) and stimulated (G1) human lymphocytes has been determined by dose fractionation studies. In both types of cells repair time was approx. 4–5 h. Treatment with hydroxyurea, a DNA synthesis inhibitor, did not prevent or delay the rejoining of broken chromosomes, whereas treatment with cycloheximide, a potent protein synthesis inhibitor, did. Thus, the repair of radiation-induced chromosome breaks in human lymphocytes is similar to the repair observed with plant cells. |
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Keywords: | FUdR, 5-fluorodeoxyuridine PHA, phytohemagglutinin |
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