N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase |
| |
| Authors: | Connolly P J Wetter S K Beers K N Hamel S C Chen R H Wachter M P Ansell J Singer M M Steber M Ritchie D M Argentieri D C |
| |
| Affiliation: | The R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA. |
| |
| Abstract: | Two series of compounds (1 and 2) having structural features of the dual COX/5-LO inhibitor tepoxalin and the 5-LO inhibitor ABT-761 were prepared. Many of these hybrid compounds are potent COX and 5-LO inhibitors; two compounds (1a and 2t) inhibit eicosanoid biosynthesis in an ex vivo assay. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
