GeneTrailExpress: a web-based pipeline for the statistical evaluation of microarray experiments |
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Authors: | Andreas Keller Christina Backes Maher Al-Awadhi Andreas Gerasch Jan Küntzer Oliver Kohlbacher Michael Kaufmann Hans-Peter Lenhof |
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Affiliation: | 1.Center for Bioinformatics,Saarland University,Saarbrücken,Germany;2.Wilhelm Schickard Institute for Computer Science,Eberhard Karls University,Tübingen,Germany |
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Abstract: | Background High-throughput methods that allow for measuring the expression of thousands of genes or proteins simultaneously have opened new avenues for studying biochemical processes. While the noisiness of the data necessitates an extensive pre-processing of the raw data, the high dimensionality requires effective statistical analysis methods that facilitate the identification of crucial biological features and relations. For these reasons, the evaluation and interpretation of expression data is a complex, labor-intensive multi-step process. While a variety of tools for normalizing, analysing, or visualizing expression profiles has been developed in the last years, most of these tools offer only functionality for accomplishing certain steps of the evaluation pipeline. |
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