The stress responsive and morphologically regulated hsp90 gene from Paracoccidioides brasiliensis is essential to cell viability |
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Authors: | André M Nicola Rosângela V Andrade Alessandra S Dantas Patrícia A Andrade Fabrício BM Arraes Larissa Fernandes Ildinete Silva-Pereira Maria Sueli S Felipe |
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Affiliation: | 1.Department of Cell Biology,University of Brasília,Brazil |
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Abstract: | Background Paracoccidioides brasiliensis is a dimorphic fungus that causes the most prevalent systemic mycosis in Latin America. The response to heat shock is involved in pathogenesis, as this pathogen switches from mycelium to yeast forms in a temperature dependent fashion that is essential to establish infection. HSP90 is a molecular chaperone that helps in the folding and stabilization of selected polypeptides. HSP90 family members have been shown to present important roles in fungi, especially in the pathogenic species, as an immunodominant antigen and also as a potential antifungal therapeutic target. |
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