PlGF-MMP-9-expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle |
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Authors: | Gargioli Cesare Coletta Marcello De Grandis Fabrizio Cannata Stefano M Cossu Giulio |
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Affiliation: | San Raffaele Biomedical Park Foundation of Rome, 100 Via Castel Romano, 10028 Rome, Italy. |
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Abstract: | Sclerosis and reduced microvessel density characterize advanced stages of muscular dystrophy and hamper cell or gene delivery, precluding treatment of most individuals with Duchenne muscular dystrophy. Modified tendon fibroblasts expressing an angiogenic factor (placenta growth factor, PlGF) and a metalloproteinase (matrix metalloproteinase-9, MMP-9) are able to restore a vascular network and reduce collagen deposition, allowing efficient cell therapy in aged dystrophic mice. These data open the possibility of extending new therapies to currently untreatable individuals. |
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