The conformation of bovine serum albumin adsorbed to the surface of single all‐dielectric nanoparticles following light‐induced heating |
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| Authors: | Andrei A Krasilin Katerina Volodina Arina A Sukhova Mihail I Petrov Dmitry A Zuev Vyacheslav A Dyachuk Valentin A Milichko |
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| Institution: | 1. Department of Nanophotonics and Metamaterials, ITMO University, St. Petersburg, Russia;2. Institute of Macromolecular Compounds of the Russian Academy of Sciences, St. Petersburg, Russia;3. Department of Neuroscience, Karolinska Institute, Stockholm, Sweden |
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| Abstract: | Interaction between nanoparticles and biomolecules leads to the formation of biocompatible or bioadverse complexes. Despite the rapid development of nanotechnologies for biology and medicine, relatively little is known about the structure of such complexes. Here, we report on the changes in conformation of a blood protein (bovine serum albumin) adsorbed on the surface of single all‐dielectric nanoparticles (silicon and germanium) following light‐induced heating to 640 K. This protein is considerably more resistant to heat when adsorbed on the nanoparticle than when in solution or in the solid state. Intriguingly, with germanium nanoparticles this heat resistance is more pronounced than with silicon. These observations will facilitate biocompatible usage of all‐dielectric nanoparticles.  |
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| Keywords: | blood proteins germanium nanoparticles nanothermometry Raman spectroscopy silicon |
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