S6 phosphorylation accompanies recruitment of ribosomes and mRNA into polysomes in response to dichlororibofuranosyl benzimidazole |
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| Authors: | Roger Duncan Edwin H McConkey |
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| Institution: | Department of Molecular, Cellular and Developmental Biology University of Colorado, Boulder, CO 80309, USA |
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| Abstract: | Dichlororibofuranosyl benzimidazole (DRB), a potent inhibitor of nuclear RNA synthesis and messenger RNA (mRNA) accumulation, produces a paradoxical mobilization of rRNA and mRNA from the subpolysomal pool into polysomes in HeLa cells during the first 40 min of treatment. S6 is phosphorylated concurrently with polysome accumulation, and ribosomal subunits containing phosphorylated S6 are preferentially localized in polysomes, indicating that they form initiation complexes more readily than their non-phosphorylated counterparts. |
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| Keywords: | To whom offprint requests should be sent |
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