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Probable localization of synaptic inputs evoking generation of slow inhibitory postsynaptic potentials in pyramidal neurons: Simulation studies
Authors:I. L. Kopysova  S. M. Korogod  E. S. Yanovskii
Abstract:In computer-experiments using the interactive program, CRONA, and using data from natural experiments that measured the reversal potential of slow (long-term) inhibitory postsynaptic potentials (slow IPSPs), we determined the probable location of the region of potassium-conducting synapses that are responsible for their generation. Parameters such as the geometric dimensions of neuronal dendritic branches and the intracellular concentration of K+ were studied for their effect on the determination of this region. It is concluded that these synaptic inputs are non-somatic, and that allowing for the variability of the initial parameters they probably lie on the apical dendrites at a distance between 110 and 460 µm from the soma.Dnepropetrovsk State University. A. A. Bogomolets Institute of Physiology, Ukrainian Academy of Sciences, Kiev. Translated from Neirofiziologiya, Vol. 23, No. 6, pp. 738–745, November–December, 1991.
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