Dose dependent inhibition of B-16 melanoma growth in vivo by a synthetic analogue of PGE2 |
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Authors: | M Gabriella Santoro PhD Gordon W Philpott MD Bernard M Jaffe MD |
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Institution: | Department of Surgery, Washington University School of Medicine, 4960 Audubon Avenue, St. Louis, Missouri, USA |
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Abstract: | Daily intratumor administration of 16, 16-dimethyl-PGE2-methyl ester in two different dosages inhibited tumor growth in C57B1/6J mice bearing subcutaneous B-16 melanomas. The larger dose (20γg/day/mouse) produced a 68% decrease in tumor volume, a 69% decrease in tumor weight and a 60% decrease in the number of cells in mitotic phase. The smaller dose (10μg/day/mouse) was one fifth less effective than the 20μg dose but produced similar changes. Histological examination of tumors revealed no significant differences either in the inflammatory cell population or the amount of necrosis in the control and di-M-PGE2-treated tumors. |
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