The Role of Lipid Bodies in the Microglial Aging Process and Related Diseases |
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| Authors: | Xirong Hu Benhong Xu Wei Ge |
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| Affiliation: | 1.State Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Beijing,China;2.School of Life Sciences,Tsinghua University,Beijing,China;3.Institute of Basic Medical Sciences, School of Basic Medicine,Peking Union Medical College,Beijing,China |
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| Abstract: | Lipid bodies (LBs) have long been considered to be organelles merely for the storage of neutral lipids. However, recent studies have shown the significance of LBs in signal transduction, especially in glial cells, including microglia. Microglial cells are the resident mononuclear phagocytes in the central nervous system and have a close relationship with the aging process and neurodegenerative diseases. Evidence suggests that LBs accumulate and are remodeled during the aging process and the development of neuroinflammatory conditions. However, the mechanisms underlying the formation of LBs under these conditions and the mechanism by which LB remodeling influences the progression of neurodegeneration remain to be clarified. In this review, we have summarized the findings from recent studies with the aim of further elucidating these issues. |
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