O-alkyl O-nucleoside 3'-phosphonates as novel starting materials for oligonucleotide synthesis |
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| Authors: | T Wada R Kato H Hotoda M Sekine T Hata |
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| Institution: | Department of Life Chemistry, Tokyo Institute of Technology, Yokohama, Japan. |
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| Abstract: | It was found that the title compounds were activated rapidly into the corresponding highly reactive phosphorochloridites by use of tris(2,4,6-tribromophenoxy)dichloro-phosphorane (BDCP) as a chlorinating reagent. The reaction was applied to the synthesis of oligodeoxyribonucleotides. |
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