Regulation and control of glucose overutilization in erythrocytes by vanadate |
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Authors: | Najma Zaheer Baquer Amit Kumar Saxena Poonam Srivastava |
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Institution: | (1) School of Life Sciences, Jawaharlal Nehru University, 110 067 New Delhi, India |
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Abstract: | The insulin mimetic effect of vanadate inin vitro incubation of erythrocytes with high glucose concentrations showed an increase in sorbitol accumulation and glucose utilization using U-14C-glucose. Aldose reductase inhibitors and vanadate addition reversed the sorbitol accumulation, whereas insulin could not reverse it. Increased glucose utilization was also normalized with vanadium compounds. Increased activity of aldose reductase and sorbitol levels in diabetic animals were also normalized with vanadate treatment. |
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Keywords: | insulin mimetic vanadate RBC glucose utilization aldose reductase |
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