Molecular recognition and targeting of lysosomal proteins. |
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Authors: | K von Figura |
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Affiliation: | Georg-August-Universitat, G?ttingen, Germany. |
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Abstract: | Recent studies have established that in mammalian cells insulin-like growth factor-II can couple the large mannose-6-phosphate receptor to a GTP-binding protein and that the insulin-like growth factor-II-induced activation of the GTP-binding protein is inhibited by mannose-6-phosphate and lysosomal enzymes. In mouse, the gene for the large mannose-6-phosphate receptor is maternally imprinted. |
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