色氨酸对应激小鼠行为学和脑内单胺类递质的影响

本文以小鼠为实验材料建模,依次进行了Morris水迷宫、跳台、强迫游泳实验。结果显示,应激可导致小鼠学习记忆能力下降,容易出现绝望情绪,下丘脑5-HT含量下降,NE含量上升,灌胃高低剂量色氨酸(100,200mg·kg-1 bw)均可显著提高小鼠学习记忆能力,缓和绝望情绪。低剂量色氨酸在增加下丘脑5-羟色胺(5-HT)含量和降低去甲肾上腺素(NE)含量方面效果更显著。结果表明,适量色氨酸可以有效改善应激小鼠相关行为学评分,其机制可能与下丘脑5-HT和NE的含量有关。

Effect of Tryptophan on Behavior and Hypothalamus Monoamine Neural Transmitter of Stressed Mice

Based on mice for experimental material,we conducted behavior tests including Morris Maze,jumping platform and forced swimming in a row.The result showed that stress could lead to learning and memory ability to drop,and it was easy to appear in despair.Besides,the level of 5-HT dropped while the level of NE arose in hypothalamus.After intraperitoneal injection of tryptophan(100,200 mg·kg-1 bw),the learning and memory ability of mice improved significantly,the despair emotion moderated notably.Lower dose tryptophan had more effect on the level of 5-HT increasing and NE decreasing than the high dose.The results indicated that moderate tryptophan could effectively improve related behavior scores of stressed mice,this may be carried out though hypothalamus serotonin and norepinephrine.