| 大气可吸入颗粒物对肺组织损伤机制的研究进展 |
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| 引用本文： | 姜薇,赵晓红. 大气可吸入颗粒物对肺组织损伤机制的研究进展[J]. 生命科学, 2007, 19(1): 78-82 |
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| 作者姓名： | 姜薇 赵晓红 |
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| 作者单位： | 首都师范大学生命科学学院,北京,100037;北京联合大学应用文理学院,北京,100083 |
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| 摘 要： | 大量的流行病学研究表明，大气可吸入颗粒物（PM10）的污染水平与心肺系统疾病的死亡率存在密切联系，但其确切的毒理机制尚未阐明。本文对近年来国内外有关大气可吸入颗粒物对肺组织的损伤机制的研究进行了综述，从氧化损伤和炎性损伤两个方面对大气可吸入颗粒物的毒理学机制进行阐述。
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| 关 键 词： | 大气可吸入颗粒物 氧化损伤 炎性损伤 损伤机制 |
| 文章编号： | 1004-0374（2007）01-0078-05 |
| 收稿时间： | 2006-04-17 |
| 修稿时间： | 2006-05-08 |
The study on the mechanism of lung injury by induction of inhaled particle matter |
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| JIANG Wei,ZHAO Xiaohong. The study on the mechanism of lung injury by induction of inhaled particle matter[J]. Chinese Bulletin of Life Sciences, 2007, 19(1): 78-82 |
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| Authors: | JIANG Wei ZHAO Xiaohong |
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| Affiliation: | 1 School of Life Sciences, Capital Normal University, Beijing 100037, China; 2 College of Applied Arts and Sciences, Beijing Union University, Beijing100083, China |
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| Abstract: | Many epidemiologic studies have shown that the increase in mortality of cardiovascular and respiratory diseases is closely associated with elevated level of ambient respirable particulate matter, however, the toxicological mechanisms of PMlo still remain unresolved. The study progress in oxidative damage and inflammatory injury effects of PMlo on alveolar tissue were reviewed. |
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| Keywords: | respirable particulate matter oxidative damage inflammation damage mechanism of injury |
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