Effects of silkworm larvae powder containing manganese superoxide dismutase on immune activity of mice |
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Authors: | Wan-Fu Yue Jian-Mei Liu Guang-Li Li Xing-Hua Li Xiao-Feng Wu Jian-Tong Sun Hong-Xiang Sun Yun-Gen Miao |
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Institution: | (1) Institute of Sericulture and Apiculture, College of Animal Sciences, Zhejiang University, Hangzhou, 310029, P. R. China;(2) Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, P. R. China |
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Abstract: | To study the function of silkworm larvae powder containing superoxide dismutase and potential practical development, we investigated
the safety assessment and effects on immune activity of mice such as the growth of immunity-related organs, delayed-type hypersensitivity
(DTH) and charcoal particle clearance ability. The mean body weights in treated mice were significantly heavier than that
of control, meanwhile, the ratio of splenocytes/body weight and the thoracic gland/body weight in treated mice was significantly
enhanced after 30 days treated with silkworm larvae powder containing manganese superoxide dismutase. The treated mice resulted
in a profound activation of the DTH and charcoal particle clearance, and indicated the treated mice have stronger phagocytic
activity to exogenous materials. Our data also indicated the feeding treatment was safe with 360 folds of recommended human
dosage in acute toxic test. In long-term test, there were no effects of silkworm larvae powder containing SOD on treated mice’s
growth and inside organs as long as 90 days. Further the electronic microscope investigation showed the intestine, liver,
splenocyte and stomach in mice were no obvious changes both in organs and sub-organs such as nucleus, endoplasmic reticulum,
mitochondrion, Golgi and peroxisomes after treated for as long as 90 days. |
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Keywords: | Silkworm (Bombyx mori L ) Manganese superoxide dismutase (SOD) Immunity Mouse Regulation |
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