Towards a new conceptual approach to "parasitoproteomics" |
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Authors: | Biron David G Moura Hercules Marché Laurent Hughes Austin L Thomas Frédéric |
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Institution: | GEMI, UMR CNRS, IRD 2724, IRD, 911 Avenue Agropolis BP 64501, 34394 Montpellier Cedex 5, France. biron@mpl.ird.fr |
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Abstract: | Many parasitologists are betting heavily on proteomic studies to explain biochemical host-parasite interactions and, thus, to contribute to disease control. However, many "parasitoproteomic" studies are performed with powerful techniques but without a conceptual approach to determine whether the host genomic responses during a parasite infection represent a nonspecific response that might be induced by any parasite or any other stress. In this article, a new conceptual approach, based on evolutionary concepts of immune responses of a host to a parasite, is suggested for parasitologists to study the host proteome reaction after parasite invasion. Also, this new conceptual approach can be used to study other host-parasite interactions such as behavioral manipulation. |
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