GC-1 mRHBDD1 knockdown spermatogonia cells lose their spermatogenic capacity in mouse seminiferous tubules |
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| Authors: | Yong Wang Wei Song Shuchun Li Xin Guan Shiying Miao Shudong Zong SS Koide Linfang Wang |
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| Institution: | (1) State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, 5 Dong Dan San Tiao, 100005 Beijing, PR, China;(2) National Research Institute for Family Planning Beijing, WHO Collaboration Center of Human Reproduction, 12 Da Hui Si, 100081 Hai Dian, Beijing, PR, China;(3) Center for Biomedical Research, the Population Council, 1230 York Avenue, New York, NY 10021, USA |
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| Abstract: | Background Apoptosis is important for regulating spermatogenesis. The protein mRHBDD1 (mouse homolog of human RHBDD1)/rRHBDD1 (rat homolog
of human RHBDD1) is highly expressed in the testis and is involved in apoptosis of spermatogonia. GC-1, a spermatogonia cell
line, has the capacity to differentiate into spermatids within the seminiferous tubules. We constructed mRHBDD1 knockdown
GC-1 cells and evaluated their capacity to differentiate into spermatids in mouse seminiferous tubules. |
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