Approach to dual-acting platelet activating factor (PAF) receptor antagonist/thromboxane synthase inhibitor (TxSI) based on the link of PAF antagonists and TxSIs |
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| Authors: | Fujita Masakazu Seki Taketsugu Inada Haruaki Shimizu Kazuhiro Takahama Akane Sano Tetsuro |
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| Institution: | Omiya Research Laboratory, Nikken Chemicals Co., Ltd., Kitabukuro-cho, Saitama-shi, Saitama 330-0835, Japan. souyaku@jade.dti.ne.jp |
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| Abstract: | A series of compounds (22-36) which possess dual-acting PAF antagonist/TxSI have been generated by the approach of linking the known PAF antagonists and TxSIs, such as Ridogrel (1). |
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