Immunological responses in cancer patients after vaccination with the therapeutic telomerase-specific vaccine Vx-001 |
| |
Authors: | Eleni-Kyriaki Vetsika Georgios Konsolakis Despoina Aggouraki Athanasios Kotsakis Elisavet Papadimitraki Soultana Christou Jeanne Menez-Jamet Kostas Kosmatopoulos Vassilis Georgoulias Dimitris Mavroudis |
| |
Institution: | (1) Laboratory of Tumor Biology, Medical School, University of Crete, Voutes, 71110 Heraklion, Crete, Greece;(2) Department of Medical Oncology, University General Hospital of Heraklion, Crete, Greece;(3) Vaxon Biotech, Paris, France;(4) Department of Medical Oncology, “IASO” General Hospital of Athens, Athens, Greece |
| |
Abstract: | Vx-001, an HLA-A*0201 restricted telomerase (TERT)-specific anti-tumor vaccine, is composed of the 9-mer cryptic TERT572 peptide and its optimized variant TERT572Y. We have previously shown that Vx-001 is non-toxic, highly immunogenic and in vaccinated NSCLC patients early specific immune
response is associated with prolonged survival. The aim of the present study was to investigate the specific T-cell immune
response against Vx-001. Fifty-five patients with chemo-resistant advanced solid tumors were vaccinated with TERT572Y (2 subcutaneous injections) followed by TERT572 peptide (4 subcutaneous injections) every 3 weeks. Specific immune response was evaluated by IFN-γ and perforin ELISpot and
intracellular cytokine staining assays. TERT-reactive T cells were detected in 27 (51%) out of 53 evaluable patients after
the 2nd vaccination and in 22 (69%) out of 32 evaluable patients after the completion of 6 vaccinations. Immune responses
developed irrespective of the stage of disease and disease status before vaccination. Patients with disease progression at
study entry who developed a post-vaccination-induced immunological response had a significant overall survival benefit compared
to the post-vaccination non-responders. The Vx-001 vaccine is a promising candidate for cancer immunotherapy since it can
induce a TERT-specific T-cell immune response that is associated with prolonged survival. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|