Common variants for atrial fibrillation: results from genome-wide association studies |
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| Authors: | Xinyuan Liu Fei Wang Ashley C. Knight Jiangmin Zhao Junjie Xiao |
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| Affiliation: | (1) Department of Pediatrics, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China;(2) Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, Shanghai, 200092, China;(3) Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China;(4) Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;(5) Department of Radiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; |
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| Abstract: | Atrial fibrillation (AF) affects more than 5 million people worldwide; however, none of the anti-arrhythmic drugs available now are entirely optimal in terms of efficacy and safety. A better understanding of the molecular mechanism of AF will facilitate the process of finding new strategies to prevent AF. As the non-familial AF is the major form of AF, identifying common variants for AF in these populations by genome-wide association studies will definitely accelerate this process. This review summarizes the recently identified common AF variants on 4q25, 16q22, and 1q21 and discusses their implications for the clinic. |
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