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Recombinant H22(scFv) blocks CD64 and prevents the capture of anti-TNF monoclonal antibody: A potential strategy to enhance anti-TNF therapy |
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| Authors: | Dmitrij Hristodorov Radoslav Mladenov Hannes Brehm Rainer Fischer Stefan Barth Theo Thepen |
| Affiliation: | 1.Department of Experimental Medicine and Immunotherapy; Institute of Applied Medical Engineering; University Hospital RWTH Aachen; Aachen, Germany;2.Department of Pharmaceutical Product Development; Fraunhofer Institute for Molecular Biology and Applied Ecology IME; Aachen, Germany;3.Institute of Molecular Biotechnology (Biology VII); RWTH Aachen University; Aachen, Germany |
| Abstract: | |
| Keywords: | CD64 H22 chronic inflammation TNF monoclonal antibodies immunotherapy |