Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities |
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| Authors: | Cho Jun-Cheol Rho Ho Sik Joo Yung Hyup Lee Chang Seok Lee Jaekyoung Ahn Soo Mi Kim Jung Eun Shin Song Seok Park Young-Ho Suh Kyung-Do Park Soo Nam |
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| Affiliation: | Division of Chemical Engineering, College of Engineering, Hanyang University, Seoul 133-791, Republic of Korea. |
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| Abstract: | We synthesized benzoate ester derivatives of kojic acid with and without adamantane moiety. Benzoate derivatives 2a-e that did not contain an adamantane moiety showed potent tyrosinase inhibitory activities. However, depigmenting activity was not noted in a cell-based assay. Contrasting results were obtained for benzoate derivatives (3a-e) containing an adamantane moiety. Compounds 3a-e showed potent depigmenting activities without tyrosinase inhibitory activities. To the best of our knowledge, this is the first study showing the depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities. |
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