| p63基因的结构与功能 |
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| 引用本文： | 王帅,薛永来,冯喜增.p63基因的结构与功能[J].生命科学,2007,19(4):446-450. |
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| 作者姓名： | 王帅 薛永来 冯喜增 |
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| 作者单位： | 南开大学生命科学学院生物活性材料教育部重点实验室,天津,300071;南开大学生命科学学院生物活性材料教育部重点实验室,天津,300071;南开大学生命科学学院生物活性材料教育部重点实验室,天津,300071 |
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| 摘 要： | p63基因是肿瘤抑制基因p53家族成员之一,与p53基因表现出高度同源性.较之p53基因,p63基因更为复杂.p63的两个不同启动子和多种内含子剪接方式,导致p63基因编码产生多种亚型P63蛋白.这些P63亚型蛋白,在不同的组织不同的发育阶段发挥不同的生物学功能.本文就p63基因结构、p63在细胞周期和凋亡中的作用,以及在表皮发育中的功能等方面的研究进展作一概述.
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| 关 键 词： | p63 结构 功能 细胞周期调控 亚型 |
| 文章编号： | 1004-0374（2007）04-0446-05 |
| 收稿时间： | 2007-03-21 |
| 修稿时间： | 2007-04-29 |
The structure and function of p63 gene |
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| WANG Shuai,XUE Yonglai,FENG Xizeng.The structure and function of p63 gene[J].Chinese Bulletin of Life Sciences,2007,19(4):446-450. |
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| Authors: | WANG Shuai XUE Yonglai FENG Xizeng |
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| Institution: | The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China |
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| Abstract: | p63 gene is one of tumor suppressor gene p53 family members. It displays high homology to p53 gene. Comparing with p53, p63 is more complex. Because of its two promoters and many different splicing modes of introns, p63 gene encodes many kinds of P63 isoforms. These P63 isoforms perform their diverse biological functions in different tissues and different developmental phases. This paper introduces researching progress of p63 genetic structure and its biological functions especially in cell cycle, apoptosis and epidermis development. |
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| Keywords: | p63 |
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