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Proposed follow up programme after curative resection for lower third oesophageal cancer |
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| Authors: | LH Moyes JE Anderson MJ Forshaw |
| Institution: | 1. Department of Surgery, Medical School, Attikon General Hospital, University of Athens, Athens, Greece 2. Department of Surgery, Medical School, Laikon General Hospital, University of Athens, Athens, Greece 3. Department of Vascular Surgery, Medical School, Attikon General Hospital, University of Athens, Athens, Greece 4. Department of Propaedeutic Surgery, Medical School, Laiko General Hospital, University of Athens, Athens, Greece |
| Abstract: | Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the aberrant expression of G1/S cyclins and especially cyclin D and cyclin E; the pathways through which they lead to tumour formation and their involvement in different types of cancer. These elements indicate the mechanisms that could act as targets for cancer therapy. |
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