Center for Biofunctional Molecules and Department of Chemistry Pohang University of Science and Technology San 31 Hyojadong, Pohang 790-784, Korea
Abstract:
N-Acyl-N-hydroxy-β-amino acid derivatives were prepared and tested as inhibitors for thermolysin to find that these inhibitors show the
-stereospecificity in contrast to the corresponding hydroxamates prepared from -amino acid, which exhibit the
-stereochemistry. N-Formyl-N-hydroxy-β-
-Phe-NHMe is the most potent inhibitor having the Ki value of 1.66 μM.