| 开放翼腭动脉改良制备大鼠自体血栓脑梗死模型比较 |
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| 引用本文： | 周震,;王雪岩,;王坤,;王凯,;张玉莲.开放翼腭动脉改良制备大鼠自体血栓脑梗死模型比较[J].中国实验动物学杂志,2014(9):62-65. |
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| 作者姓名： | 周震 ;王雪岩 ;王坤 ;王凯 ;张玉莲 |
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| 作者单位： | [1]天津中医药大学第二附属医院,天津300150; [2]天津中医药大学,天津300193 |
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| 基金项目： | 国家自然科学基金（81273942）;天津市应用基础及前沿技术研究计划（12JCZDJC25300）;天津市教委“十二五”创新团队培养计划（NO-TDl2-5035）. |
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| 摘 要： | 目的：利用大鼠自体血栓，在开放翼腭动脉（ pterygopalatine artery，PPA）的情况下堵塞其大脑中动脉，造成大脑中动脉远端供血区的脑梗死模型。方法开放PPA，结扎颈外动脉（ external carotid artery，ECA），将栓子通过颈总动脉（common carotid artery，CCA）血流将栓子冲大脑中动脉（middle cerebral artery，MCA）远端，造成梗死模型，按Bederson评分对其神经功能进行评分，TTC染色确定梗死体积。结果两手术组模型比较，评分均升高，且出现白色梗死区，经统计检测分析无明显差异。结论开放PPA大鼠自体血栓制造脑梗死模型可缩短手术时间，降低死亡率。
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| 关 键 词： | 翼腭动脉 脑梗死模型 大鼠 比较研究 |
A comparative study of opening the pterygopalatine arteries improved preparation of autologous blood clots in cerebral infarction model |
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| Institution: | ZHOU Zhen, WANG Xue-yan, WANG Kun, WANG Kai, ZHANG Yu-lian (1. Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China; 2. Tianjin University of Traditional Chinese Medicine, Tianjin 300193,China ) |
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| Abstract: | Objective To open pterygopalatine artery using autologous blood clot clogged the middle cerebral artery, resulting in cerebral infarction model of middle cerebral artery in the distal blood supply area.Methods Open PPA, ligation of ECA, embolus through CCA blood flow, rushed into the MCA distal embolus, cause infarction model. According to Bederson rating score the neural function.TTC staining to determine the infarction volume.Results Comparison of two operation models, scores were increased, and white infarcted area appears.There is no significant differences detected by statistical analysis.Conclusion Open PPA manufacturing cerebral infarction model rats of autologous blood clots could shorten the operation time, reduce the mortality rate. |
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| Keywords: | Pterygopalatine artery Cerebral infarction model Rats Comparative study |
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