Studies on in vitro models of cellular immunity: the role of T and B cells in the secretion of lymphotoxin |
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| Authors: | S J Shacks J Chiller G A Granger |
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| Institution: | Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92644 U.S.A. |
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| Abstract: | When normal murine spleen cells were treated with anti-theta serum and complement, they failed to produce LT or synthesize cellular DNA when stimulated in vitro with PHA. Theta-positive cells were responsible for LT production in spleens removed from X-irradiated and bone marrow- or thymus-reconstituted animals. Finally, spleens from congenitally athymic Nu/Nu mice failed to produce LT when stimulated with pokeweed mitogen or phytohemagglutinin. |
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