Effect of prostacyclin on perfusion pressure, electrical activity, rate and force of contraction in isolated rat and rabbit hearts. |
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| Authors: | M Karazyn D F Horrobin M S Manku S C Cunnane R A Karmali A I Ally R O Morgan K C Nicolaou W E Barnette |
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| Institution: | 1. Clinical Research Institute 110 Pine Avenue West Montreal, Quebec H2W 1R7 Canada;1. Department of Chemistry University of Pennsylvania Philadelphia, Pennsylvania 19174 U.S.A. |
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| Abstract: | Prostacyclin when added to medium perfusing rat and rabbit hearts caused an increase in perfusion pressure at concentrations from 1 pg/ml ? 1 ng/ml (2.8 × 10?12 ? 2.8 × 10?9M) and a decrease at higher concentrations. Rhythm disturbances were observed with low prostacyclin concentrations in 6 of 10 rat hearts and 2 of 5 rabbit hearts studied. Increased heart rates were seen in the isolated rat hearts but not in the rabbit hearts. Force of contraction of isolated rat hearts was increased with increasing prostacyclin concentrations up to 100 pg/ml. Higher concentrations decreased contractile force. No inotropic effects were seen with rabbit hearts. |
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