| 体外去除胆固醇菌株的筛选及其作用机理研究 |
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| 引用本文： | 王一鸣,范小兵,杭晓敏,李堃宝,杨虹,沈耀氏. 体外去除胆固醇菌株的筛选及其作用机理研究[J]. 微生物学通报, 2006, 33(6): 43-47 |
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| 作者姓名： | 王一鸣 范小兵 杭晓敏 李堃宝 杨虹 沈耀氏 |
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| 作者单位： | 1. 上海交通大学生命科学技术学院,上海,200240
2. 上海交大昂立股份有限公司生物医药研究所,上海,200030 |
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| 基金项目： | 上海交大-昂立SARS基金资助项目 上海市重点产业技术产学研联合攻关项目（No.沪产学研06-20） |
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| 摘 要： | 从青年人肠道中筛选分离，鉴定得到8株乳杆菌，进行胆固醇去除、耐酸和耐胆汁盐实验，发现两株植物乳杆菌Lp529和Lp501同时具有较高的体外去除胆固醇能力和耐胆汁盐及耐酸性能。通过对它们胆固醇去除过程和胆固醇在相应固液相中分布情况的实验分析，表明：Lp501与Lp529去除胆固醇的机理有差别，存在菌株特异性。研究还发现，被菌株吸收的胆同醇没有被代谢为其他物质，并可在条件适合时重新释放出来。
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| 关 键 词： | 植物乳杆菌 胆固醇 共沉淀 |
| 文章编号： | 0253-2654（2006）06-0043-05 |
| 收稿时间： | 2006-01-23 |
| 修稿时间： | 2006-02-28 |
in vitro Selection of Probiltic Lactobacillus from the Human Feces and Their Mechanism on Cholesterol-lowering |
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| WANG Yi-Ming, FAN Xiao-Bing, HANG Xiao-Min, LI Kun-Bao, YANG Hong. in vitro Selection of Probiltic Lactobacillus from the Human Feces and Their Mechanism on Cholesterol-lowering[J]. Microbiology China, 2006, 33(6): 43-47 |
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| Authors: | WANG Yi-Ming FAN Xiao-Bing HANG Xiao-Min LI Kun-Bao YANG Hong |
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| Affiliation: | College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240 ; Shanghai Jiao Da Onlly Co. , Ltd, Shanghai 200030 |
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| Abstract: | 8 strains of Lactobacillus isolated from feces of healthy youth and identified by molecular biological methods were studied in the experiments, including removal cholesterol from media, acid-tolerance and bile-tolerance. Two L. plantarum strains, Lp529 and Lp501, show higher ability of removal cholesterol, acid-tolerance and bile-tolerance. Analyzed their process of cholesterol removing and cholesterol distributing in the precipitation, their mechanisms on cholesterol removing are different, The study also demonstrated that the cholesterol assimilated into the cell did not transform into other molecule and could be released in some condition. |
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| Keywords: | Lactobacillus plantarum Cholesterol Co-precipitation |
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