Nuclear 115cadmium: uptake and disappearance correlated with cadmium-binding protein synthesis. |
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Authors: | S E Bryan H A Hidalgo |
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Institution: | Department of Biological Sciences University of New Orleans New Orleans, Louisiana 70122 USA |
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Abstract: | The intracellular distribution of 115cadmium was determined following a pulsed exposure to the metal. The uptake and disappearance of label from rat liver nuclei was correlated with the appearance of a cytoplasmic Cd-binding protein. By coupling - experiments it was shown that unspecifically bound cadmium is free to enter the nucleus while specifically bound cadmium remains in the cytoplasm. |
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Keywords: | CdBP Cd-Binding Protein 1 5 mM NaCl 0 15 mM Nacitrate pH 7 0 |
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