Decorin gene expression and its regulation in human keratinocytes |
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Authors: | Velez-DelValle Cristina Marsch-Moreno Meytha Castro-Muñozledo Federico Kuri-Harcuch Walid |
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Institution: | Department of Cell Biology, Centro de Investigación y de Estudios Avanzados del IPN, Apdo. Postal 14-740, México D.F. 07000, Mexico |
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Abstract: | In various cell types, including cancer cells, decorin is involved in regulation of cell attachment, migration and proliferation. In skin, decorin is seen in dermis, but not in keratinocytes. We show that decorin gene (DCN) is expressed in the cultured keratinocytes, and the protein is found in the cytoplasm of differentiating keratinocytes and in suprabasal layers of human epidermis. RT-PCR experiments showed that DCN expression is regulated by pro-inflammatory and proliferative cytokines. Our data suggest that decorin should play a significant role in keratinocyte terminal differentiation, cutaneous homeostasis and dermatological diseases. |
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Keywords: | Epidermal keratinocytes Terminal differentiation Decorin Gene expression Psoriasis |
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