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A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids
Affiliation:1. Biotech Research & Innovation Centre, University of Copenhagen, 2200 Copenhagen, Denmark;2. Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, 2200 Copenhagen, Denmark;3. Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland;4. Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland;5. Finsen Laboratory, Rigshospitalet, Copenhagen University Hospital, 2200 Copenhagen, Denmark;6. Institute of Biomedicine and FICAN West Cancer Centre, University of Turku and Turku University Hospital, 20521 Turku, Finland;7. Department of Pathology, University of Turku and Turku University Hospital, 20521 Turku, Finland;8. Department of Pathology, University of Helsinki and HUS Diagnostic Center, Helsinki University Hospital, 00260 Helsinki, Finland;9. Department of Pathology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark;10. Department of Obstetrics and Gynecology, University of Turku and Turku University Hospital, 20521 Turku, Finland
Abstract:
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  • Keywords:organoids  tumor models  high-grade serous ovarian cancer  organoid biobank  3D cell culture, culture conditions  HPLM  scRNA-seq  personalized medicine  functional precision medicine
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