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Quantitative proteomic profiling identifies global protein network dynamics in murine embryonic heart development
Affiliation:1. Department of Biology and Genetics, McAllister Heart Institute, UNC-Chapel Hill, Chapel Hill, NC 27599, USA;2. Department of Cell Biology and Physiology, UNC-Chapel Hill, Chapel Hill, NC 27599, USA;3. Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA;4. Department of Pharmacology, UNC-Chapel Hill, Chapel Hill, NC 27599, USA;5. Lineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC 27599, USA;6. Integrative Program for Biological and Genome Sciences, UNC-Chapel Hill, Chapel Hill, NC, 27599 USA;1. Department of Burns, Wound Repair and Reconstruction, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, China;2. Department of Neurosurgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong, China;1. Division of Life Science, Center for Stem Cell Research, HKUST-Nan Fung Life Sciences Joint Laboratory, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong, China;2. Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China;3. Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, Shenzhen-Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute, Shenzhen, China;1. Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA;2. Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA;3. Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA;1. Institute of Molecular Biology, Department of Chemistry and Biochemistry, 1229 University of Oregon, Eugene, OR 97403, USA;1. Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland;2. University of Basel, Petersplatz 1, 4001 Basel, Switzerland;1. Department of Genetics and Developmental Biology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel
Abstract:
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  • Keywords:cardiac  heart  proteomics  mevalonate pathway  metabolism  congenital heart disease  heart development
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