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Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells
Institution:1. Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA;2. UC Berkeley-UC San Francisco Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA 94158, USA;3. Developmental and Stem Cell Biology Ph.D. Program, University of California, San Francisco, San Francisco, CA 94158, USA;4. Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA;5. Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA;6. Chan Zuckerberg Biohub, San Francisco, CA 94158, USA;7. Center for iPS Cell Research and Application, Kyoto 606-8397, Japan;8. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA
Abstract:
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  • Keywords:tight junctions  TJP1  epiblast  gastrulation  cell signaling  pSMAD1  BMP4  PGCLCs
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