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ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer
Affiliation:1. State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiang’an South Road, Xiamen, Fujian 361102, China;2. Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiang’an South Road, Xiamen, Fujian 361102, China;3. Xiamen University-Amogene Joint R&D Center for Genetic Diagnostics, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiang’an South Road, Xiamen, Fujian 361102, China;4. State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiang’an South Road, Xiamen, Fujian 361102, China;5. Department of Pathology, The Second Affiliated Hospital, Shantou University Medical College, Dongxia North Road, Shantou, Guangdong 515041, China;1. Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA;2. Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China;3. Cardiovascular Research Center, School of Basic Medical Sciences, Jiaotong University, Xi’an 710061, China;4. Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada;5. Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA;6. Departments of Pediatrics and Medicine, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA;1. Division of Cardiology, Ospedale Manzoni, Lecco, Italy;2. Clinical Pharmacology, Milan, Italy;3. Division of Cardiology, Ospedale Infermi, Rimini, Italy;4. Division of Cardiology, Ospedale della Misericordia, Grosseto, Italy;5. Cardiologia Prima, Emodinamica, Ospedale Niguarda, Milano, Italy;6. Division of Cardiology, IRCCS Arcispedale S. Maria Nuova, Reggio Emilia, Italy;7. Cardiovascular Department, Humanitas Clinical and Research Center, Rozzano, Italy;8. Division of Cardiology, Ospedale Mauriziano, Torino, Italy;9. Cardiovascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy;10. Division of Cardiology, Ospedale Belcolle, Viterbo, and Centro per la Lotta Contro L''Infarto - CLI Foundation, Rome, Italy;11. Department of Obstetrics, Gynecology and Pediatricss, Obstetrics and Gynecology Unit, Azienda Ospedaliero-Universitaria of Modena, Italy;12. Department of Medico Surgical Sciences and Biotechnology, Sapienza University of Rome, Latina, Italy;13. Division of Cardiology, Ospedale San Giovanni Addolorata, and Centro per la Lotta contro l'' Infarto - CLI Foundation, Roma, Italy;1. Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China;2. Affiliated Dongguan Hospital, Southern Medical University, Dongguan 523058, China;3. Department of Orthopedics, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China;4. Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China;5. State Key Laboratory of Organ Failure Research, Academy of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, Guangdong, China;6. Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China;7. Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China;8. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA;1. Department of Pathology and Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA;2. Department of Biology, University of Kentucky, Lexington, KY 40506, USA;3. Department of Obstetrics and Gynecology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA;4. Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA;5. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA;6. Center for Women’s Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA;7. Department Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO 63110, USA;8. Center for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA;9. Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA;1. Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico School of Medicine, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA;2. Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA;3. Proteomics Core Facility, UC Davis Genome Center, University of California, Davis, Davis, CA 95616, USA;1. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA, Torrance, CA 90502, USA;2. Department of Medical Genetics, China Medical University, Shenyang 110122, China;3. Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA;4. Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Abstract:
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  • Keywords:breast cancer  antitumor immunity  type I IFN signaling pathway  JMJD8  STING
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